Valencia won 1-0 against Ludogorets at home, advancing with an aggregate score of 4-0. Despite having a significant 3-0 advantage from the first leg, Valencia fielded their strongest lineup. They nearly scored in the first half when Parejo's free kick hit the crossbar. In the 59th minute, a cross from the left by Catabia found Alcácer, who headed in his fourth goal of the season in this competition, making it 1-0. Ludogorets, who had eliminated PSV Eindhoven and Lazio, also had a chance to equalize, but Bezjak's close-range shot was bravely saved by goalkeeper Alves.
Porto drew 2-2 with Napoli away, advancing with an aggregate score of 3-2. Napoli dominated the first half but only managed to score once in the 21st minute when Higuaín's quick counterattack set up Pandev, who calmly chipped the ball over the advancing goalkeeper to make it 1-0. This was Pandev's first goal in European competitions this season, leveling the aggregate score at 1-1. In the 69th minute, Brazilian midfielder Fernando delivered a precise through ball, allowing Algerian forward Ghilas to score through the legs of the defender, equalizing for Porto at 1-1. Porto's morale surged, and in the 73rd minute, Belgian midfielder Defour's shot hit the post. Three minutes later, Quaresma showcased his skills, dribbling past Behrami and Ghorra before unleashing a powerful shot to make it 2-1. In the 92nd minute, Callejón's cross from the right found substitute forward Zapata, whose close-range shot was in vain, ending the match at 2-2.
Benfica drew 2-2 with Tottenham at home, advancing with an aggregate score of 5-3. Tottenham's 42-year-old American goalkeeper Friedel continued to set the record for the oldest player in this competition. However, his goal was breached in the 34th minute when Salvio crossed from the right after beating Norton, and Argentine defender Garay headed in to make it 1-0. In the 78th minute, substitute Carney assisted Belgian international Chadli, who cut in from the left and fired a right-footed shot to equalize at 1-1. Just a minute later, Lennon crossed from the wing, and Carney headed back for Chadli to score again, making it 2-1. In the 94th minute, Sandro fouled Salvio in the box, and Brazilian forward Lima converted the penalty, leveling the match at 2-2.
